文昌鱼免疫系统

书籍目录

About the Author

Foreword

Preface

1 Amphioxus is a model for understanding the evolution of vertebrate

1.1 Brief introduction ofamphioxus

1.2 Biology of amphioxus

1.2.1 Reproduction and embryogenesis of amphioxus

1.2.2 Anatomy of amphioxus

1.3 The Story ofamphioxus and its early researches in China

References

2 Basic knowledge of immunology

2.1 Immune organs

2.1.1 Primary lymphoid organs

2.1.2 Secondary lymphoid organs

2.2 Immune cells

2.2.1 Lymphoid cells

2.2.2 Innate immunity associated cells

2.3 Innate immunity

2.3.1 Toll-like receptors involved signaling pathway

2.3.2 Nod-like receptors and their functions

2.3.3 RIG-like receptors

2.3.4 C-type lectins

2.3.5 The scavenger receptors

2.3.6 Inflammation

2.4 Adaptive immunity

2.4.1 Specificity

2.4.2 Diversity

2.4.3 Immunological memory

2.4.4 Selfononself recognition

2.5 Complement system

2.5.1 Complement pathways

2.5.2 Complement in host defense

References

3 Immune organs and cells of amphioxus

3.1 Introduction

3.2 Organs of the amphioxus immune system

3.2.1 Amphioxus gill slits: the first immune defense line

3.2.2 Amphioxus intestine: not just a digestive organ but also an immune organ

3.3 Cells of the amphioxus immune system

3.3.1 Phagocytes

3.3.2 Lymphocyte-like cells

References

Genomic and transeriptomic view of the amphioxus immunity.

4.1 Introduction

4.2 Trace evidence of adaptive immunity

4.2.1 TCRs, Igs and VLRs

4.2.2 MHC and genes involved in antigen presentation

4.3 Extraordinary gene expansion in the amphioxus innate immunity..

4.3.1 The TLR system

4.3.2 TheNLR system

4.3.3 LRRIG proteins

4.3.4 Other LRR-containing genes

4.3.5 C-type lectins

4.3.6 Scavenger receptors

4.3.7 RIG-I-like helicases

4.3.8 Complement-related receptors

4.3.9 The TNF system

4.3.10 Expansion and reshuffling of the death-fold domains

4.3.1l Expansion of TIR adaptors, TRAFs and initiator caspases

Abbreviation Index

Key Words Index

作者简介

《文昌鱼免疫系统(英文版)》是一本关于文昌鱼免疫学研究的专著。文昌鱼属于脊索动物门头索动物亚门，是现存与脊椎动物亲缘最近的无脊椎动物之一，被誉为研究脊椎动物起源和演化的“活化石”，也是研究脊椎动物免疫起源与演化，特别是由天然免疫到适应性免疫的过渡的最重要的模式生物。《文昌鱼免疫系统(英文版)》详细介绍了文昌鱼研究历史和文昌鱼生物学，重点从比较免疫学的视角全面介绍了文昌鱼免疫系统的研究进展，主要包括以文昌鱼为代表的头索动物天然免疫及其向脊椎动物的演化，头索动物原始适应性免疫的基本框架。《文昌鱼免疫系统(英文版)》同时向读者介绍了近年文昌鱼研究的一系列重大发现：如发现头索动物免疫大爆炸现象，文昌鱼中发现适应性免疫的标志细胞——淋巴样细胞及其信号转导的关键分子，在头索动物文昌鱼中存在外源性细胞凋亡通路等。另外，《文昌鱼免疫系统(英文版)》也分析了未来文昌鱼免疫研究的发展方向。

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