遗传学一览 Medical Genetics at a Glance

书籍目录

Preface Acknowledgements Part Ⅰ Developmental biology  1  Basic biology   2  The cell   3  The chromosomes   4  DNAstructure   5  DNAreplication   6  RNAstructure   7  Production of messenger RNA   8  Protein synthesis   9  The cell cycle 　10  Gametogenesis 　11  Embryology 　12  Sexual differentiation Part Ⅱ Medical genetics　13  The place of genetics in medicine 　14  Chromosomal aneuploidies 　15  Chromosome structural abnormalities 　16  Mendel's laws 　17  Autosomal dominant inheritance 　18  Autosomalrecessiveinheritance 　19  Intermediate inheritance 　20  Sex-related inheritance 　21  Congenital abnormalities 　22  Multifactorial threshold traits 　23  The common disorders of adult life 　24  Twin studies 　25  Normal polymorphism 　26  Allele frequency 　27  Genetic linkage and disease association 　28  Gene mapping 　29  Mutagenesis and DNA repair 　30  Mutations 　31  The molecular biology of cancer 　32  Familial cancers 　33  lmmunogenetics Part Ⅲ Clinical applications of genetics　34  Clinical applications of genetics: an overview 　35  Pedigree drawing 　36  Risk assessment 　37  Dysmorphology 　38  Chromosome analysis 　39  Biochemical diagnosis 　40  Reproductive genetic counselling 　41  Prenatal sampling 　42  Linkage analysis 　43  DNA sequencing 　44  Southern blotting 　45  The polymerase chain reaction 　46  DNAprofiling 　47  Avoidance and prevention of disease 　48  The management of genetic disease Glossary Appendix: Information resources Index

作者简介

Medical Genetics at a Glance is a concise, well-illustrated and accessible genetics textbook. It follows the now familiar, easy-to-use, double page spread format of the At a Glance series. Each double page presents clear, memorable diagrams that illustrate essential information with accompanying text that covers key topics and issues in more detail.     Structured into three distinct sections, Medical Genetics at a Glance takes the student through developmental biology, medical genetics and the clinical application of genetics. The first section focuses on basic biological concepts such as cell and chromosome structure, molecular biology and the cell cycle, as well as human embryonic development and sexual maturation. The second section applies these principles to medicine through the essential 'laws' of inheritance, the chromosome anomalies, multifactorial inheritance, normal polymorphism and gene frequency, then moving on to gene mapping, mutagenesis, cancer and immunogenetics. The final section addresses the clinical application of the above principles in pedigree drawing and molecular diagnostic procedures based on the human gene map, PCR and Southern techniques, risk assessment, genetic counselling, gene therapy and much more. 　　Medical Genetics at a Glance is an ideal resource that fits the budget and reading time of medical students and those seeking a quick, thorough introduction to this fast moving field. It can be used as primary or supplementary reading in a lecture-based course and is perfect for exam preparation.

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